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青島雙元泰和藥業有限公司

青島市城陽區雙元路218號

電話: 0532-55676230
傳真: 0532-55676180

非天然氨基酸


特殊氨基酸和保護基團


與20種天然氨基酸不同,這些氨基酸不通過遺傳密碼編碼,通常他們作為代謝產物在自然界中發現,特別是在植物和細菌中。

雙元泰和提供的特殊氨基酸包括以下分子,如果沒有找到你需要的氨基酸,請咨詢:

E-Acetyl-Lysine

Unnatural Amino Acids

-Alanine (3-amino-propionic acid)

-Alanine is the only natural occurring -amino acid, present e.g in panthothenic acid.
?-alanine (3-amino-propionic acid)e

Aminobenzoic acid

aminobenzoic acid

6-Aminocaproic acid (Aca, 6-Aminohexanoic acid)

This amino acid is often used as a linker to increase the distance between the peptide and an additional modification, e.g. a fluorescent dye.
6-aminocaproic acid (aca, 6-aminohexanoic acid)

?-Aminobutyric acid (Abu)

?-aminobutyric acid (or GABA) is an inhibitory transmitter of the central nerval system. It enhances permeability of postsynaptic membranes for chloride ions, thus leading to hyperpolarisation and consequently to an increase of the membrane's activation potential.
aminobutyric acid (abu)

Citrulline (Cit)

Citrulline is a metabolic reagent in the urea metabolism pathway of many terrestric vertebrates. In this pathway, unwanted ammonia is being detoxified and eliminated.

citrulline (cit)

Cysteine, Acm (Acetamidomethyl) protected

this specially protected Cys is used to selectively form disulfide bridges.

Cysteine, Acm (Acetamidomethyl) protected

Dimethyl-Lysine

Dimethyl-Lysine

Hydroxy-Proline (Hyp)

Hydroxy-proline is present almost exclusively in structural proteins (e.g. collagens or connective tissues in plant cell walls or mammals). It is formed during a posttranslational modification of proline in cells.

Hydroxy-Proline (Hyp)

Mercaptopropionic acid

Mercaptopropionic acid

Methyl-Lysine

Methyl-Lysine

3-Nitro-Tyrosine

3-Nitro-Tyrosine

Norleucine (Nle = 2-amino hexanoic acid)

Norleucine (Nle = 2-amino hexanoic acid)

pyro-Glutamic acid (Pyr)

pyro-Glutamic acid (Pyr) is a common N-terminal amino acid modification in many biologically active peptides (hormones).

pyro-Glutamic acid (Pyr)

Z (Carbobenzoxyl)

special protecting group for N-terminus.

Z (Carbobenzoxyl)

D-amino acids

Amino acids carrying four different groups on their a-C atom (i.e. asymmetric C atom, or C*) are chiral substances. These a-amino acids can be found in respective L- and D-forms (enantiomers):
D-amino acids
The predominant form in natural proteins is the L-form.

As some enzyme classes are enantioselective, i.e. they can distinguish between L- and D-forms and specifically accept only one of the two forms as substrate, this enantioselectivity makes D-amino acids a valuable tool in medicine (e.g. in peptide antibiotics) and enzyme assays.

Heavy Amino Acids

In contrast to special amino acids composed of 12C and 14N atoms, heavy amino acids can be substituted with 13C and/or 15N atoms. These heavy amino acids are non-radioactive, but 1 Da heavier than the standard amino acids. This molecular weight difference makes them useful tools for quantitative analysis of peptides by Mass Spectrometry (MS) and Nucleic Magnetic Resonance Spectroscopy (NMR) e.g. for determination of protein structure and dynamics. The standard heavy amino acids you can find:

Heavy Amino Acids
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